For doctor-recommended pain relief, Extra Strength TYLENOL®, works fast to relieve head and body aches. Many people drink alcohol, especially when they socialize. Many people have also taken acetaminophen (Tylenol) to relieve minor aches, pains, or fever. I had like 3 shots of some pretty strong alcohol, then without thinking much when i woke up 10 hours or so later I took a few tylenol to ease the headache. TYLENOL® Extra Strength Coated Tablets for Adults should be used to temporarily reduce fever and relieve minor aches and pains. Each extra-strength pain relief coated tablet contains 500 milligrams of acetaminophen and can be a safe and effective post-surgery pain relief option when used as directed. Comprehensive alcohol & food interactions for Tylenol Extra Strength (acetaminophen). Daily alcohol use. How to use Tylenol Extra Strength. Take this product by mouth as directed. Follow all directions on the product package. If you are uncertain about any of the information. Taking Tylenol Extra Strength and drinking alcohol Experiences Side Effects & Concerns Compare Medications Drug Facts There may be a negative interaction between Tylenol Extra Strength and alcohol. tylenol, acetaminophen, interaction, alcohol, liver Details: How long should I wait between taking 1000mg of Tylenol in the afternoon and consuming a few drinks in the evening. There are many different forms of Tylenol on the market including Tylenol Children’s, Tylenol Extra Strength, Tylenol Cold and Flu, Tylenol Allergy, and Tylenol PM, among others. Despite how widely used Tylenol is, and the fact that it’s considered relatively safe, there is the potential to overdose on acetaminophen. Arthritis Home Tylenol and Alcohol If you are taking Tylenol, alcohol should generally be avoided. Studies show that people who drink alcohol regularly are at an increased risk for Tylenol poisoning even if they are taking a normal dosage.